Optimization of the product portfolio has been recognized as a critical problem in industry, manage-ment, economy and so on. It aims at the selection of an optimal mix of the products to o er in the target market. As a probability function, reliability is an essential objective of the problem which linear models often fail to evaluate it. Here, we develop a Multiobjective integer nonlinear constraint model for the problem. Our model provides opportunities to consider the knowledge transferring cost and the environmental e ects, as nowadays important concerns of the world, in addition to the classical factors operational cost and reliability. Also, the model is designed in a way to simultane-ously optimize the input materials and the products. Although being to some extent complicated, the model can be e ciently solved by the metaheuristic algorithms. Finally, we make some numerical experiments on a simulated test problem.